In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae)

The species of the genus Tabernaemontana have a long tradition use in different pathologies infectious origins; antibacterial, antifungal, and antiviral effects related to control where this are used, been attributed indole monoterpene alkaloids, mainly those iboga type. There more than 1000 alkaloids isolated from other genera Apocynaceae family, several which lack studies antibacterial activity. In present study, four were seeds cymosa Jacq, namely voacangine (1), voacangine-7-hydroxyindolenine (2), 3-oxovoacangine (3), rupicoline (4), tested an vitro activity study against bacteria S. aureus, sensitive resistant methicillin, classified by World Health Organization as critical for investigation new antibiotics. Of tested, only was active with MIC 50 µg/mL. addition, silico carried out between some proteins bacterium, finding that also showed binding involved cell wall synthesis, PBP2 PBP2a.